DIFLUCAN 50MG 7CAPS.

Basic information about DIFLUCAN 50MG 7CAPS.

·         Active content: FLUCONAZOLE.

·         Price: 68   LE   for   7 capsules.

·         Medical classification: antifungals.Triazoles.

·         Company: PFIZER, EGYPT .

Mechanism of Action of DIFLUCAN 50mg 7Caps.

Fluconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis.

DIFLUCAN 50mg 7Caps. Interactions

1.       Cimetidine: Decreased efficacy of fluconazole.

2.       Cyclosporine: Increase in serum cyclosporine plasma concentration.

3.       Hydrochlorothiazide: Reduction in renal clearance of fluconazole.

4.       Phenytoin: Efficacy of phenytoin enhanced.

5.       Rifampicin: Efficacy of fluconazole decreased, higher dosage required.

6.       Sulfonylureas: Efficacy of tolbutamide, glyburide and glipizide increased.

7.       Warfarin: Potentiates the anticoagulant effect resulting in increase in prothrombin time.

DIFLUCAN 50mg 7Caps. Indications

1.Oesophageal candidiasis

2.Oropharyngeal candidiasis

3.Vaginal candidiasis

4.Systemic candidiasis

5.Cryptoc.

DIFLUCAN 50mg 7Caps. alternatives in Egypt

Medicine trade name	Company	price
AMRIFLUCAN 50mg 7 hard gelatin Caps.	AMRIYA , EGYPT	24   LE   for   7 capsules
DIFLUCAN 50mg 7Caps.	PFIZER , EGYPT	68   LE   for   7 capsules
FLOCAZOLE 50mg 7Caps.	EIMC , EGYPT	40   LE   for   7 capsules
TRICONAL 50mg 7Caps.	T3A PHARMA , EGYPT	35.3   LE   for   7 capsules