DIFLUCAN 5MG/ML 70ML SYRUP

Basic information about DIFLUCAN 5MG/ML 70ML SYRUP

·         Active content: FLUCONAZOLE.

·         Price: 68   LE   for   70 ml.

·         Medical classification: antifungals.Triazoles.

·         Company: PFIZER, EGYPT .

Mechanism of Action of DIFLUCAN 5mg/ml 70ml syrup

Fluconazole is fungicidal or fungistatic depending on the drug concentrations. I t inhibits the conversion of Lanosterol to 14 demethyl Lanosterol by inhibiting the cytochromeP450 enzyme 14 alpha demethylase and impair ergosterol synthesis.

DIFLUCAN 5mg/ml 70ml syrup Interactions

1.       Cimetidine: Decreased efficacy of fluconazole.

2.       Cyclosporine: Increase in serum cyclosporine plasma concentration.

3.       Hydrochlorothiazide: Reduction in renal clearance of fluconazole.

4.       Phenytoin: Efficacy of phenytoin enhanced.

5.       Rifampicin: Efficacy of fluconazole decreased, higher dosage required.

6.       Sulfonylureas: Efficacy of tolbutamide, glyburide and glipizide increased.

7.       Warfarin: Potentiates the anticoagulant effect resulting in increase in prothrombin time.

DIFLUCAN 5mg/ml 70ml syrup Indications

1.Oesophageal candidiasis

2.Oropharyngeal candidiasis

3.Vaginal candidiasis

4.Systemic candidiasis

5.Cryptoc.

DIFLUCAN 5mg/ml 70ml syrup alternatives in Egypt

No ava. alternative.